The AdDIT (Adolescent Diabetes Cardio-Renal Intervention Trial) and iCARE (Improving Renal Complications in Adolescents with Type 2 Diabetes through Research) studies are working together to identify the most important risk factors for early kidney disease in youth with diabetes. There are important differences in the timing of onset and rates of progression of chronic kidney disease (CKD) in youth with type 1 and type 2 diabetes.
Can-SOLVE CKD has provided the opportunity to link two existing projects together so that, guided by our patient partners, we can study a broad range of factors that could both contribute to the risk of CKD, as well as signal high-risk patients that need more intensive treatment. We are measuring biological, psychological and social factors in youth, as well as a panel of biomarkers (markers of inflammation, proteins, hormones and kidney filter micro-particles) in order to broadly address our project goal. This joint project will lead to a better understanding of why kidney injury happens in youth with diabetes, and what can potentially be done to stop or slow down this process in order to decrease the risk of kidney failure in adulthood.