Spironolactone is a drug that is very effective at reducing scarring of the heart and might help prevent heart-related deaths in patients with kidney failure. We will determine if spironolactone reduces heart related deaths and hospitalizations due to heart failure.
Heart disease is a major cause of hospitalization, reduced quality of life, and shortened survival in people with kidney disease. We will develop tools to help doctors share personalized information with patients on the benefits versus risks of having a heart procedure, and help patients better communicate their own values and preferences.
AdDIT is studying an observational cohort of youth with type 1 diabetes along with a group of healthy age-matched subjects and longitudinally assessing both kidney function and cardiovascular function.